Scientific Production
Articles
2025
Paillet J, Gaudeaux P, Abou Alezz M, Moirangthem RD, Cascione S, Corredera MM, Dolens AC, De Mulder K, Velghe I, Lavaert M, Vandekerckhove B, Noémie R, Corneau A, Sadek H, Rault P, Joshi A, De La Grange P, Staal F, Taghon T, Olivier N, Ditadi A, André I, Soheili TS. Ex vivo-generated lymphoid progenitors encompass both T cell and innate lymphoid cell fates. Front Immunol. 2025. doi: 10.3389/fimmu.2025.1617707
2025
Costa-Verdera H, Meneghini V, Fitzpatrick Z, Abou Alezz M, Fabyanic E, Hunag X, Dzhashiashvili Y, Ahiya A, Mangiameli E, Valeri E, Crivicich G, Piccolo S, Cuccovillo I, Caccia R, Kai Chan Y, Bertin B, Ronzitti G, Engel EA, Merelli I, Mingozzi F, Gritti A, Kuranda K, Kajaste-Rudnitski A. AAV vectors trigger DNA damage response-dependent pro-in ammatory signalling in human iPSC-derived CNS models and mouse brain. Nat Commun. 2025. doi: 10.1038/s41467-025-58778-3
2024
El Boustani M, Mouawad N, Abou Alezz M. AP3M2: A key regulator from the nervous system modulates autophagy in colorectal cancer. Tissue Cell. 2024. doi: 10.1016/j.tice.2024.102593
2024
Valeri E, Breggion S, Barzaghi F, Abou Alezz M, Crivicich G, Pagani I, Forneris F, Sartirana C, Costantini M, Costi S, Marino A, Chiarotto E, Colavito D, Cimaz R, Merelli I, Vicenzi E, Aiuti A, Kajaste‐Rudnitski A. A novel STING variant triggers endothelial toxicity and SAVI disease. J Exp Med. 2024. doi: 10.1084/jem.20232167
2024
Scarfò R, Randolph LN, Abou Alezz M, El Khoury M, Gersch A, Li Z, Luff S, Tavosanis A, Ramondo GF, Valsoni S, Cascione S, Didelon E, Passerini L, Amodio G, Brandas C, Villa A, Gregori S, Merelli I, Freund JN, Sturgeon C, Tavian M, Ditadi A. CD32 captures committed haemogenic endothelial cells during human embryonic development. Nat Cell Biol. 2024. doi: 10.1038/s41556‐024‐01403‐0
2023
Valeri E, Unali G, Piras F, Abou Alezz M, Pais G, Benedicenti F, Lidonnici MR, Cuccovillo I, Castiglioni I, Arévalo S, Spinozzi G, Merelli I, Behrendt R, Oo A, Kim B, Landau NR, Ferrari G, Montini E, Kajaste-Rudnitski A. Removal of innate immune barriers allows efficient transduction of quiescent human hematopoietic stem cells. Mol Ther. 2023. doi: 10.1016/j.ymthe.2023.11.020
2023
Unali G, Crivicich G, Pagani I, Abou Alezz M, Folchini F, Valeri E, Matafora V, Reisz JA, Giordano AMS, Cuccovillo I, Butta GM, Donnici L, D’Alessandro A, De Francesco R, Manganaro L, Cittaro D, Merelli I, Petrillo C, Bachi A, Vicenzi E, Kajaste-Rudnitski A. Interferon-inducible phospholipids govern IFITM3-dependent endosomal antiviral immunity. EMBO J. 2023. doi.org/10.15252/embj.2022112234
2023
Giordano AMS, Abou Alezz M, Merelli I, Kajaste-Rudnitski A. Protocol to differentiate monolayer human induced pluripotent stem cells into inflammatory responsive astrocytes. STAR Protoc. 2023. doi.org/10.1016/j.xpro.2023.102142
2022
Giordano AMS, Luciani M, Gatto F, Abou Alezz M, Begh C, Della Volpe L, Migliara A, Valsoni S, Genua M, Dzieciatkowska M, Frati G, Tahraoui-Bories J, Giliani SC, Orcesi S, Fazzi E, Ostuni R, D’Alessandro A, Di Micco R, Merelli I, Lombardo A, Reijns MAM, Gromak N, Gritti A, Kajaste-Rudnitski A. DNA damage contributes to neurotoxic inflammation in Aicardi-Gouti res syndrome astrocytes. J Exp Med. 2022. doi.org/10.1084/jem.20211121
2020
Abou Alezz M, Celli L, Belotti G, Lisa A and Bione S. GC-AG Introns Features in Long Non-coding and Protein-Coding Genes
Suggest Their Role in Gene Expression Regulation. Front. Genet. 2020 11:488. doi:10.3389/fgene.2020.00488
Book Chapters
2024
Abou Alezz M, Artificial Intelligence Bioinformatics Systems for the Diagnosis and Treatment of Rare Diseases: Integration and Implementation. In: Vulpiani G (ed.) Diritto, Intelligenza Artificiale e Medicina. Un dialogo interdisciplinare. Napoli: Edizioni Scientifiche Italiane. 2024. ISBN: 978-88-495-5722-0
Software
2025
Abou Alezz M. NatChat: Chatting with Nature Journals Current Issue using a local Language Model.
R-package version 1.1.0. https://monahton.github.io/NatChat. 2025. doi:10.5281/zenodo.15482472
2025
Abou Alezz M. GencoDymo2: Comprehensive Analysis of GENCODE Annotations and Splice Site Motifs.
R-package version 1.0.1. https://github.com/monahton/GencoDymo2. 2025. doi:10.5281/zenodo.15302316
2020
Abou Alezz M, Salviati L, Alfieri R, Bione S. GencoDymo: Data Extraction and Manipulation from the GENCODE Database.
R-package version 0.2.1. https://github.com/monahton/GencoDymo. 2020. doi:10.5281/zenodo.3605995
Oral Presentations and Posters
2020
Abou Alezz M, Celli L, Belotti G, Salviati L, Nicastro A, Alfieri R, Lisa A, Bione S. GC-AG introns features in long non-coding and protein-coding genes suggest their role in gene expression regulation - 22nd EMBL PhD Symposium: The Roaring 20s - Online conference, November 27-28, 2020
2020
Abou Alezz M, Celli L, Belotti G, Salviati L, Nicastro A, Alfieri R, Lisa A, Bione S. GC-AG introns features in long non-coding and protein-coding genes suggest their role in gene expression regulation - Cancer Science Institute of Singapore: 6th RNA Biology Symposium 2020 - Online conference, October 1-2, 2020
2020
Abou Alezz M, Celli L, Belotti G, Salviati L, Nicastro A, Alfieri R, Lisa A, Bione S. GC-AG introns features in long non-coding and protein-coding genes suggest their role in gene expression regulation - 25th Annual meeting of the RNA Society - Online conference, May 26-31, 2020
2020
Abou Alezz M, Celli L, Belotti G, Salviati L, Nicastro A, Alfieri R, Lisa A, Bione S. Unexpected features of GC-AG introns in long non-coding and protein-coding genes suggest a new role as regulatory elements – Oral Presentation at “Pavia 3rd Annual Joint Symposium – LIFE SCIENCE 2020 - Pavia (Italy), February 19-21, 2020
2019
Abou Alezz M, Celli L, Belotti G, Salviati L, Nicastro A, Alfieri R, Lisa A, Bione S. Characterization of the genomic and splicing features of long non-coding RNAs using bioinformatics approaches - Oral Presentation at EMBL Symposia 2019: The Non-Coding Genome - Heidelberg (Germany), October 16-19, 2019
2018
Abou Alezz M, Celli L, Bione S. Computational approach towards genomic characterization of human long non-coding RNA - EMBO Workshop 2018: From epigenome towards epitranscriptome in cell fate choice - Capri (Italy), October 14-17, 2018